New Non-Sedated Test for Barrett's Esophagus
A new cell collection test for Barrett's esophagus could simplify the screening process for patients needing endoscopy.
Updated on Oct. 15, 2026 in Cancer
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Cyted Health has shared clinical validation data from its DETECT-ME study, which evaluated a new cell collection device for identifying patients at risk of Barrett's esophagus. The study results offer a new, non-sedated approach for patients who may need referral for a diagnostic endoscopy.
Why it matters
Barrett's esophagus is a condition that requires monitoring to prevent esophageal cancer, but current screening pathways often rely on invasive procedures. This test aims to improve early detection and expand access for at-risk populations by simplifying the initial collection process.
The DETECT-ME clinical study enrolled 324 participants across 18 U.S. sites to evaluate the EndoSign Cell Collection Device against standard endoscopy and biopsy. While clinical validation data has now been presented, the full comparative performance profile remains under investigation.
The players
Cyted Health
A healthcare company focused on developing diagnostic tools for gastrointestinal conditions including Barrett's esophagus.
The details
The EndoSign test uses a cell collection procedure that does not require sedation, making it a potentially more accessible alternative for initial screenings. Once the device collects the necessary cells, the samples are sent to a CLIA-certified and CAP-accredited laboratory for molecular testing. The process is specifically designed to help clinicians determine which patients require a follow-up endoscopy and biopsy to assess for Barrett's esophagus.
Timeline
October 15, 2026: DETECT-ME study data presented at the ACG Annual Scientific Meeting.
Health Landscape
This development reflects an ongoing shift toward less invasive diagnostic tools in gastroenterology that can be performed in primary care settings. It sits alongside broader efforts to improve the efficiency of identifying Barrett's esophagus in patients who might otherwise avoid traditional endoscopy.
If you are concerned about persistent heartburn or gastroesophageal reflux disease, ask your physician if you meet the criteria for Barrett's esophagus screening. These newer collection methods are designed to simplify the diagnostic process, but clinical decisions should always be made in consultation with your doctor.
The takeaway
The DETECT-ME study provides initial validation for a non-sedated cell collection device for Barrett's esophagus. Patients with risk factors like chronic acid reflux should discuss current screening options with a gastroenterologist to determine the most appropriate diagnostic path.
Further reading
Learn more about the latest innovations in early detection at our Cancer resource hub.
Source note: This article includes information reported by Business Weekly.
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