Suzetrigine Linked to Lower Opioid Use After Knee Surgery
Patients who used the medication after knee replacement were more likely to avoid opioid refills during recovery.
Updated on Oct. 6, 2026 in Arthritis
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A retrospective study presented in September 2026 evaluated 104 patients following knee arthroplasty to determine if suzetrigine influenced post-surgical opioid needs. Researchers found that those treated with the medication were more likely to be opioid-free in the weeks following their procedure compared to historical controls.
Why it matters
Reducing reliance on opioids after orthopedic surgery remains a key goal in improving patient safety and recovery protocols. This study suggests that non-opioid interventions may help manage surgical pain effectively without sacrificing functional outcomes.
This retrospective study of 104 patients undergoing knee arthroplasty compared suzetrigine users to historical controls. While suzetrigine patients showed higher rates of opioid-free status, there were no statistically significant differences in reported pain scores or functional recovery.
The players
Froedtert & the Medical College of Wisconsin
An academic medical center that conducted the institutional pharmacy review and medical record analysis.
The details
Researchers reviewed medical records and provider documentation at Froedtert & the Medical College of Wisconsin to evaluate clinical outcomes. By comparing patients who received suzetrigine against a historical cohort, investigators assessed whether the medication reduced the necessity for opioid refills during the first 6 weeks of recovery. The analysis showed that approximately half of the patients were able to secure insurance coverage for the treatment at an out-of-pocket cost of around $30.
Timeline
September 8-11, 2026: The study was presented at the PAINWeek 2026 conference.
2-week visit: Patients were assessed for their ability to avoid opioid refills.
6 weeks: Researchers measured the percentage of patients who remained opioid-free.
Health Landscape
The findings presented at the PAINWeek 2026 conference highlight the ongoing clinical shift toward opioid-sparing protocols in orthopedic surgery. This research aligns with broader efforts to integrate non-opioid medications into standard postoperative care without compromising patient function.
If you are preparing for knee surgery, it is worth discussing whether non-opioid pain management options are appropriate for your specific surgical plan. You should talk with your surgeon about available alternatives and check with your insurance provider regarding potential out-of-pocket costs.
The takeaway
This study suggests that certain non-opioid medications may help reduce the need for opioid refills during the initial recovery phase of knee replacement. If you have an upcoming surgery, consult your doctor about pain management strategies that prioritize limiting opioid use while maintaining mobility.
Further reading
For more on managing recovery after joint procedures, visit Arthritis.
Source note: This article includes information reported by Pharmacytimes.
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Should medical providers prioritize non-opioid pain treatments, even if costs are higher for the patient?
