Depression Could Increase Mortality in Stone Formers

Adults with kidney stones show higher rates of depression, which may significantly impact their long-term health risks.

Updated on Oct. 24, 2026 in Mental Health

Depression Could Increase Mortality in Stone Formers

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Researchers have identified a significant link between moderate to severe depression and an increased mortality risk among people who form kidney stones. The study highlights a potential disparity, noting that individuals with kidney stones experience higher rates of depression than the general population.

Why it matters

Understanding this connection is vital for patient care because depression may hinder an individual's ability to follow essential dietary and medical therapies for stone prevention. Identifying this mental health burden early could improve long-term health outcomes for those managing recurring kidney stones.

A study of over 23,000 adults found that kidney stone formers had an adjusted odds ratio of 1.14 for depression, rising to 1.32 for women, while those with moderate to severe depression faced a 1.99 adjusted hazard ratio for all-cause mortality compared to those without.

The players

American Society of Nephrology

A professional medical organization that advances kidney health through education, research, and its annual Kidney Week conference.

The details

Researchers assessed depression severity using the Patient Health Questionnaire-9 to evaluate the mental health of participants. The findings suggest that depression might contribute to mortality by reducing patient adherence to prescribed lifestyle changes and medical treatments required to prevent stone recurrence. Because this study is observational, further research is necessary to confirm how mental health support might influence survival rates in this population.

October 24, 2026: Study data was presented at ASN Kidney Week in Denver.

Health Landscape

This research adds to the growing literature presented at ASN Kidney Week regarding the holistic management of patients with nephrolithiasis. It shifts the clinical focus from purely physical stone prevention toward integrating mental health screening into routine nephrology care.

If you manage recurring kidney stones, it is worth discussing your mental health and any symptoms of depression with your primary care provider or urologist. Acknowledging this connection can ensure that your care plan addresses both your physical prevention needs and your overall emotional well-being.

The takeaway

The research suggests that managing depression is as critical as managing diet when it comes to long-term health for kidney stone formers. Consider screening for mood changes as part of your regular check-ups to ensure your treatment plan remains effective.