Ketone Supplements Tested for Physical Health in Seniors
A new clinical trial is investigating whether these supplements can improve muscle and cognitive function in older adults.
Updated on Oct. 25, 2026 in Nutrition
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UConn researchers are testing whether ketone ester supplements can improve physical and cognitive function in older adults showing signs of frailty. Connecticut residents aged 65 and older are participating in the 20-week trial to determine if the supplements influence health span.
Why it matters
Researchers are investigating whether ketone supplements may boost health span in aging populations, potentially offering a new approach to managing frailty. This study seeks to bridge the gap between preliminary animal research and human outcomes.
This NIH-funded clinical trial involves adults aged 65 and older undergoing a 20-week intervention of ketone ester supplements or a placebo. While a 2017 study reported a 13.6% increase in the median lifespan of male mice, results from this human trial are not yet available.
The players
Jenna Bartley
The lead researcher heading the NIH-funded clinical trial testing ketone ester supplements.
UConn
A public research university hosting the clinical trial investigating health span interventions.
The details
Participants are randomly assigned to take either a ketone ester supplement or a placebo twice daily for the duration of the 20-week study. Researchers are evaluating the intervention by measuring changes in muscle strength and cognitive processing speed. This data aims to clarify if elevated ketone levels can support physical and cognitive health in the aging population.
Timeline
20-week period of participant intervention.
1-2 years until expected trial results.
Health Landscape
This study builds upon the 2017 Cell Metabolism findings that established a link between ketogenic diets and extended lifespans in mice. It reflects a growing research focus on whether metabolic interventions can specifically mitigate the physiological decline associated with human frailty.
This research is an ongoing clinical trial and does not yet provide a basis for changing your current diet or supplement regimen. If you are concerned about frailty or muscle strength, it is worth discussing appropriate screening and nutrition goals with your primary care physician.
The takeaway
While preclinical studies in mice suggest metabolic benefits, this human trial is currently the only way to determine if results translate to adults. Speak with your doctor about clinically proven ways to maintain physical strength and cognitive health as you age.
Further reading
For more information on dietary trends and research, visit our Nutrition section.
Source note: This article includes information reported by CT Insider.
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