Moisturizer Could Improve Skin Firmness for Some Adults

A study suggests twice-daily application may boost elastin in adults aged 40 to 60 with fragile or crepey skin.

Updated on Oct. 21, 2026 in Beauty

Gouache-painted editorial illustration of abstract, layered skin-like forms in sage and ochre, symbolizing firm skin structure. — A 12-week study published in September 2026 suggests that twice-daily use of a specific moisturizer may increase elastin in aging skin. AI Illustration. Upload story photo >

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Do you trust that daily use of specialized moisturizers can significantly improve your long-term skin health?

A 12-week study published September 28, 2026, found that twice-daily use of a Galderma moisturizer increased elastin expression in adults aged 40 to 60 with fragile skin. The research, which also noted improvements in skin firmness, focused on individuals with crepey, dry skin.

Why it matters

Dermatoporosis involves the loss of skin integrity and elastin, leading to fragile and crepey skin as people age. This study suggests that specific topical moisturizers may help improve skin structure for those experiencing these signs of aging.

In a 12-week multisite study of participants aged 40 to 60, researchers observed an 18 to 36 percent increase in elastin expression compared to baseline. While beta-galactosidase levels also rose by 6 to 24 percent, other markers like collagen type I remained stable.

The players

Galderma

A pharmaceutical company that specializes in dermatological treatments and skincare products.

University of California in Los Angeles

A public research university where the study's lead researcher is based.

The details

Participants in the study applied the moisturizer to the skin on their knees and thighs twice daily to test its effects on fragile skin. The product is designed to influence biological expression markers associated with skin structure and integrity. Researchers monitored the expression of various proteins, including CD44 and CD47, to assess the moisturizer's performance in supporting skin firmness and appearance.

September 28, 2026: The study was published online in the Journal of Drugs in Dermatology.
October 21, 2026: An article covering the research was published on HealthDay.

Health Landscape

This study follows a pattern of investigating topical interventions to manage the clinical symptoms of dermatoporosis. It contributes to the ongoing research into how targeted moisturizers might support skin structural integrity as part of the aging process.

If you are concerned about fragile, crepey skin, this study suggests that specific topical treatments might offer benefits for skin firmness. It is worth discussing with your dermatologist whether clinical-grade moisturizers are an appropriate addition to your current routine.

The takeaway

Topical moisturizer use in this study was associated with a measurable increase in elastin for those with fragile skin. If you notice signs of skin thinning, consult your physician to identify effective, evidence-backed options for your specific skin needs.