Amy Schumer Shares Weight-Loss Medication Experience
The actor explains her transition to Mounjaro after facing side effects with another common weight-loss treatment.
Updated on Oct. 29, 2026 in Weight Loss
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Comedian Amy Schumer recently revealed that she used the GLP-1 medication Mounjaro to achieve a 40-pound weight loss. The 44-year-old actor previously attempted to use Wegovy but discontinued the treatment due to side effects.
Why it matters
Schumer shared her experience with GLP-1 medications, noting that she sought the treatment to improve her energy and overall health. Her decision to speak publicly about using telehealth services highlights the increasing use of medical weight-loss management among adults.
Schumer reported losing 40 pounds while using the GLP-1 receptor agonist Mounjaro. It remains unknown how her specific metabolic profile influenced the transition from Wegovy to Mounjaro or what her long-term clinical outcomes will be.
The players
Amy Schumer
Comedian and actor who is 44 years old.
Midi Health
A telehealth service provider specializing in women's health and hormone-related care.
Mounjaro
A prescription GLP-1 medication used for blood sugar management and weight loss.
Wegovy
A GLP-1 receptor agonist injection used for weight management.
The details
Mounjaro is a medication that works by mimicking incretin hormones, which help regulate blood sugar and appetite by signaling the brain that the body is satiated. Like other GLP-1 receptor agonists, it is designed to slow gastric emptying, helping users feel full longer. While these medications have become popular for weight management, they require professional supervision to manage potential side effects, such as those that led Schumer to stop using Wegovy.
Timeline
March 2026: Schumer described her experience with Mounjaro on social media.
October 27, 2026: Amy Schumer appeared at a public event in New York City.
Health Landscape
The shift toward using GLP-1 receptor agonists for weight management represents a significant evolution in obesity care compared to traditional diet-only approaches. Schumer's experience mirrors a common patient journey of trial-and-error when selecting treatments that balance efficacy and tolerability.
Weight-loss medications can produce different side effects for every individual, and moving from one treatment to another should only be done under medical supervision. If you are considering weight-loss medication, it is important to discuss your medical history and potential side effects with your primary care provider.
The takeaway
Weight-loss medications often require clinical trial and error to find the right balance for your body. Discussing your specific health goals and any history of medication side effects with a physician is the safest way to evaluate if a GLP-1 receptor agonist is appropriate for you.
Further reading
For more on the current medical approaches to weight management, visit our Weight Loss section.
Source note: This article includes information reported by Internewscast Journal.
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