Inhaled Cannabis Use May Increase Propofol Doses Needed

Patients who inhale cannabis may require more anesthesia during certain endoscopic exams than nonusers.

Updated on Oct. 27, 2026 in Asthma

Gouache-painted illustration of a syringe and vial on a clinical tray, symbolizing medical dosage research. — A recent study found that patients who inhale cannabis may require higher doses of the anesthetic propofol during esophagogastroduodenoscopy procedures. AI Illustration. Upload story photo >

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Do you feel comfortable being fully transparent about your cannabis habits with your anesthesiologist?

A recent study found that patients who inhale cannabis may require higher doses of the anesthetic propofol during certain endoscopic procedures. The findings suggest that the route of cannabis use could influence medication needs for those undergoing esophagogastroduodenoscopy.

Why it matters

Understanding how substances like cannabis interact with anesthesia is critical for patient safety during medical procedures. This research highlights the need for clinicians to discuss cannabis use with patients to ensure appropriate sedation management.

This retrospective review of 264 patients analyzed propofol induction doses across 280 endoscopic procedures. Findings indicate significant dosage differences for inhalation users during esophagogastroduodenoscopy, though it remains unclear why oral cannabis use did not show similar effects.

The players

Sidney Kimmel Medical College

A Philadelphia-based medical institution that conducted the retrospective analysis on cannabis use and anesthetic requirements.

The details

Researchers stratified the retrospective review by route of administration, specifically comparing inhaled versus oral cannabis use. The study specifically identified that patients undergoing esophagogastroduodenoscopy (EGD) required 192.8 mg of propofol if they were inhalation users, compared to 151.4 mg for nonusers. No meaningful dosing differences between these groups were observed for patients undergoing colonoscopy.

October 16 to 20, 2026: The ANESTHESIOLOGY annual meeting took place in San Diego.
October 27, 2026: Study results were presented at the meeting.

Health Landscape

Anesthesia protocols rely on precise patient assessment to maintain safety and efficacy during procedures. This study adds to the evidence base concerning how patient substance use history should inform clinical practice guidelines for sedation management.

Patients who use inhaled cannabis should be transparent with their care team when preparing for upcoming endoscopic procedures. It is worth discussing your substance use history with your physician to ensure your sedation plan is accurately tailored to your needs.

The takeaway

Cannabis inhalation may affect how your body responds to anesthesia during specific gastrointestinal procedures. Always maintain an honest dialogue with your medical team about any substance use before you undergo any type of sedation.