Stevia-Based Patch Boosted Hair Regrowth in Mice

A new dissolving microneedle patch for minoxidil improved skin delivery in animal studies.

Updated on Oct. 13, 2026 in Nutrition

A close-up, top-down view of a small, square, translucent microneedle patch with a grid of tiny, pyramid-shaped needles on a sterile white surface.
Researchers developed a dissolving microneedle patch using stevioside to improve minoxidil delivery, potentially enhancing efficacy for hair regrowth treatments. AI Illustration. Upload story photo >

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Researchers recently developed a stevioside-based dissolving microneedle patch designed to improve the delivery of minoxidil. The findings, published in the journal Advanced Healthcare Materials, suggest this delivery method may enhance hair growth in subjects experiencing hair loss.

Why it matters

Improving the delivery mechanism and potency of minoxidil is a priority for researchers addressing hair loss. This new patch aims to increase drug retention in the skin, which could eventually lead to more efficient treatment options for hair regrowth.

This study compared a novel stevioside-based dissolving microneedle patch against standard minoxidil solution in a controlled test on mice. Researchers observed that the patch increased minoxidil water solubility approximately 18-fold and enhanced drug retention within the skin.

The players

Advanced Healthcare Materials

A scientific journal that publishes research on materials science and its applications in the biomedical field.

The details

Stevioside, a natural glycoside from the Stevia plant, forms spherical structures that encapsulate insoluble minoxidil molecules. The patch features a 10x10 array of pyramid-shaped microneedles that dissolve to create channels through the skin's outer layer. This process facilitates the delivery of the drug, allowing 18% of the dose to be retained in the skin compared to 8.4% for conventional solutions.

Timeline

  1. 2011: Steviol glycosides were approved as EU food additives.

  2. October 9, 2025: The original article was published.

  3. May 2026: A clinical trial on microneedling was published.

  4. October 13, 2026: The article was updated.

Health Landscape

This study fits into the active research program of advancing transdermal drug delivery systems to improve treatment outcomes. It represents a shift toward utilizing plant-derived compounds to enhance the solubility and absorption of established medical therapies.

While this patch demonstrated promise in mice, it is not currently available for human use, and further trials are needed to determine its safety and efficacy. If you are interested in hair regrowth therapies, it is worth discussing established, physician-approved options with your doctor.

The takeaway

This research demonstrates that a stevioside-based patch can significantly increase minoxidil skin retention in mice compared to conventional liquid solutions. Readers should continue to monitor updates on new delivery technologies through their primary care provider or a dermatologist.

Further reading

Learn more about the latest innovations in Nutrition and their intersection with therapeutic applications.

Source note: This article includes information reported by ZME Science.

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