Beauty Brands Added PDRN to Oral Supplements
Companies are now moving PDRN from injectable treatments to daily supplements, targeting skin health alongside collagen.
Updated on Sept. 28, 2026 in Beauty
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In August 2026, beauty brands began expanding the use of polydeoxyribonucleotide (PDRN) from topical and injectable skincare into oral supplement products. These new offerings combine the DNA-derived compounds with collagen to target skin health endpoints.
Why it matters
Brands are leveraging consumer familiarity with professional aesthetic PDRN treatments to drive the adoption of new ingestible formulations. This shift reflects a broader market trend of integrating clinical-grade beauty ingredients into daily supplement routines.
While PDRN has been used for medical skin repair for 30 years, clinical studies on PDRN specifically as an ingestible supplement are still emerging. The current products rely on established laboratory benchmarks from topical and injectable applications.
The players
Amorepacific
A South Korean beauty and cosmetics company that develops skincare, hair care, and wellness supplements.
Glowith Global
A wellness and beauty brand focused on developing ingestible supplement products.
Italian Medicines Agency
The national regulatory body responsible for authorizing medical therapies in Italy.
The details
PDRN is composed of DNA fragments typically sourced from salmon or microalgae. These supplements utilize mechanisms like adenosine A2A receptor activation and the nucleotide salvage pathway, which are intended to support cellular processes. To survive the gastrointestinal environment, developers use controlled-release tablet formulations to protect the PDRN until it is processed by the body.
Timeline
1994: The Italian Medicines Agency approved PDRN for use in skin therapies.
2014: A clinical study was published regarding PDRN and diabetic foot ulcer healing.
August 2026: Amorepacific launched a PDRN-formulated Super Collagen supplement.
September 2026: Glowith Global debuted its HERAGEN supplement at Vitafoods Asia.
Health Landscape
PDRN development is currently transitioning from clinical-grade wound care into the competitive inner beauty market. This growth trajectory mirrors the earlier industry-wide adoption of marine collagen as a primary skin health supplement.
Because oral PDRN products are a new development with limited public clinical data, consumers should approach these supplements with caution. It is worth discussing the addition of any new supplement to your routine with a physician to ensure it does not conflict with existing health conditions.
The takeaway
PDRN has moved from the doctor's office to the supplement shelf, but robust evidence for the benefits of taking it orally is still catching up. When evaluating new beauty trends, prioritize products with transparent ingredient lists and consult your doctor before starting any new regimen.
Further reading
For more on the current market trends in skin-focused wellness, visit Beauty.
Source note: This article includes information reported by NutraIngredients.
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